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Advances in Nutrition Research, 18(2), 145-160

Similarly, insulin resistance, adipocyte hypertrophy and obesity result from perturbations in the regulation of the inflammatory cytokines interleukin 6 (IL-6) and tumor necrosis factor (TNF-) in mice with increased PGRN through Pgrn over-expression or administration of recombinant PGRN [93, 95, 107, 196]

More significant changes in fine lines and firmness generally require 8-12 weeks of consistent use