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Safety signals persist even with smaller doses, as a 20222025 FAERS review reported that approximately 15% of users experienced vomiting after microdosing and roughly 10% discontinued due to adverse effects, underscoring that lower doses do not eliminate risk
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It was originally developed as a chemically modified ligand designed to stimulate the release of growth hormone (GH) while exerting minimal influence on other endocrine axes
The advisory committee narrowly recommended listing both forms, but FDA's scientific reviewers recommended against it
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