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Collectively, these data demonstrate that GLP-1MK-801 corrects hypertriglyceridaemia and hyperglycaemia with improved or similar efficacy to semaglutide in animal models of obesity and type 2 diabetes
doi: 10.1007/978-1-4939-2845-3_3 58 BakDWBechtelTJFalcoJAWeerapanaE
Since GLP-1 is secreted by intestinal tissue and rapidly degraded in the systemic circulation, its concentration is significantly higher in the intestinal tissues compared to the peripheral circulation
Es importante destacar que la vida media de la GLP-1 endgena es extremadamente corta, aproximadamente 2 a 3 minutos , ya que es rpidamente degradada por la enzima dipeptidil peptidasa-4 (DPP-4)
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