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Regular monitoring and appropriate dose adjustment of levothyroxine to maintain TSH within the reference range (typically 0.4-4.0 mU/L, though individualised targets may apply) is essential before implementing additional weight management interventions

Other protocols in our goal-based menu may use different delivery methods your provider will review the appropriate approach based on your specific protocol during your assessment

Body composition changes (muscle gain, fat loss) typically become noticeable around 8-12 weeks

Clinical evidence The effectiveness of combination therapy with PIO (1530 mg daily) and tofogliflozin (TOFO 20 mg daily) for 24 weeks was investigated in 32 patients who experienced T2D and NAFLD in an open-label RCT [116]