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Once internalized into the epithelial cells, it is phosphorylated by the host c-SRC and c-ABL tyrosine kinases at the glutamate-proline-isoleucine-tyrosine-alanine (EPIYA) motifs [24, 44], enabling it to interact with SHP2 and trigger the downstream signaling cascades [45]
In the cardiac magnetic resonance (CMR) sub-study of the SUMMIT trial, in comparison with the placebo, the treatment of obesity-related HFpEF with tirzepatide can lead to a reduction in LV mass and pericardiac adipose tissue
Interestingly, there was no correlation between the positive effect on glycemic control and an increased risk of hypoglycemia [73]
Jacobs PL, Goldstein ER, Blackburn W, Orem I, Hughes JJ
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