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The ominous octet (Defronzo model) includes: decreased muscle glucose uptake, increased hepatic glucose output, impaired incretin effect, alpha-cell hyperglucagonemia, increased renal glucose reabsorption (SGLT-2 upregulation), increased lipolysis (adipose), decreased central satiety signaling, and decreased beta-cell insulin secretion

In the future, priority should be given to advancing clinical trials, optimizing injectable formulations and administration regimens, addressing environmental and cost issues in production, and strengthening synergistic research with other preparations to enhance its application value and promote the leap from scientific research to clinical practice