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Following this, Fe 3+ is transported to the LIP via divalent metal-ion transporter-1 (DMT1) or ZRT/IRT-like proteins (ZIP), eventually being utilized by the organism after being reduced to Fe 2+ by the six-transmembrane epithelial antigen of prostate 3 (STEAP3) [25, 27]
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The addition of GIP receptor agonism may complement these effects, though the precise contributions of dual receptor activation remain under investigation
