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In other studies, phenytoin was used as a reagent to treat mouse embryos because it causes oxidation of DNA, proteins, and lipids, likely due to increased production of OH radicals (89, 90)

To establish connection with the NO-system, L-NAME (5.0 mg/kg) (worsening) and L-arginine (200.0 mg/kg) (effective only with blunted NO-synthesis, but not alone) were given intraperitoneally alone or in combination (d-arginine 200.0 mg/kg was not effective, data not shown)

This depends entirely on the treatment goal and formulation