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The GLP-1 based therapies were also not associated with a significant change in adiponectin levels in the blood with a mean difference in percent change from baseline between GLP-1 based therapies and controls of 53.63 [133.86, 26.61] % (P = 0.19
What the FDA warning tells us is that the science on these medications is still evolving
Outcomes vary individually
Free radical generation, loss of membrane potential, permeability transition, altered dynamics, and impaired biogenesis are the mitochondrial effects of RIF+INH
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