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This dual mechanism distinguishes it from other incretin-based therapies that target only the GLP-1 receptor

While the clinical relevance of these findings in a population largely free from kidney disease remains uncertain, the reductions in albuminuria, blood pressure, and the favourable safety profile support further investigation of retatrutides potential kidney-protective effects in high-risk populations

The results suggested that sitagliptin has a delayed effect on the progression of carotid atherosclerosis (CAS)