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As a result, it has a relatively low incidence of producing drowsiness compared to clonidine (Chien et al, 1990

Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis

In trauma and hemorrhagic shock models, elevated circulating mtDAMPs levels correlate with injury severity and drive a SIRS that clinically mimics sepsisa phenomenon termed sterile sepsis or autosepsis. Notably, experimental administration of purified mtDAMPs is sufficient to recapitulate neutrophil-mediated organ injury and hemodynamic collapse, establishing a direct causal link between IR-induced mitochondrial disruption and SIRS-like systemic inflammation ( The IR-mtDAMPs axis creates a feed-forward amplification loop: IR injury causes mitochondrial damage and mtDAMPs release

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