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When initiating ZEPBOUND, consider reducing the dose of concomitantly administered insulin or insulin secretagogues (e.g., sulfonylureas) to reduce the risk of hypoglycemia [see Warnings and Precautions (5.7)]
The key principle behind this schedule is patience
In addition to its greater weight loss effects, semaglutide only requires a once weekly injection while liraglutide requires a daily injection (4)
By mimicking GLP-1, this results in delayed gastric emptying, lower appetite, an increase in insulin release, and control in the amount of glucagon released
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