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This suggests that OTS derivatives could be promising anti-inflammatory drugs that require further preclinical testing

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While one trial did show VAX-D to be more effective than TENS, concerns about study design, limited generalizability, and safety risks have kept it from being widely accepted as a standard treatment (Aetna Clinical Policy Bulletins, 2025)

Subsequent advances in chemistry and automation during the 1980s and 1990s made peptide synthesis routine, Kates said, which in turn allowed researchers to produce them far more efficiently