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Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone
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Purine nucleosides, namely adenosine and guanosine, have relevant neuroprotective roles by acting both centrally and peripherally, via activation of their receptors and intracellular signaling mechanisms [269, 270]
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