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Treated mice experienced a two-fold increase in myofiber size and 70% stronger contractile force in healed tissue compared to controls
Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs
This bypass also avoids first-pass metabolism, a process in which nutrients are partially broken down by the liver before they can be used
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