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Of note, TH gene expression was substantially upregulated in the AP following GLP-1RA administration (Figure 8A), as demonstrated previously using complementary methods (64)
The activation of GIP receptors further enhances this effect by improving energy balance and fat metabolism
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5-8,10 Ultimately, obesity and T2D are associated with detrimental structural changes in bone, such as decreased trabecular bone connectivity and cortical bone thickness, increasing the risk of fractures and impairing healing
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