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Wegovy (semaglutide 2.4 mg) is a glucagon-like peptide-1 (GLP-1) receptor agonist
Its binding profile is deliberately imbalanced, showing strong affinity for the GIP receptor with an EC50 of 22.4 pM while demonstrating roughly five times weaker GLP-1 receptor activation compared to native GLP-1, with an EC50 of 934 pM versus 70.5 pM for the endogenous hormone
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