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doi: 10.1016/S0021-9258(18)52338-3 156 MarkussenJJrgensenKHSrensenARThimL
Conclusions Subcutaneous infusion using a subcutaneous catheter system and a portable pump for OHCbl administration in combined and isolated remethylation disorders is safe, acceptable, and effective
Skin & Systemic Effects Improved metabolic efficiency and reduced oxidative stress may contribute to better skin tone, clarity, and overall tissue quality, reflecting enhanced cellular function rather than direct cosmetic action
Bioavailability is route-dependent and lower than injection or IV
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