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Representative search terms included: Rhodiola rosea OR Rhodiola , Ginkgo biloba , Withania somnifera OR Ashwagandha in combination with depression , antidepressant , monoaminergic neurotransmission , BDNF , neuroplasticity , HPA axis , neuroinflammation , oxidative stress , mitochondrial dysfunction , and clinical trial . Boolean operators and database-specific filters were applied where appropriate to optimize sensitivity and specificity
Nrf2: INrf2 (Keap1) signaling in oxidative stress
12,26 Furthermore, the formation of NAPQI adducts contributes to oxidative stress, mitochondrial dysfunction, disrupted Ca 2+ homeostasis, necrotic cell death, centrilobular necrosis, and eventual liver failure (Figs
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