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We found that melatonin treatment precipitated major transcriptomic shifts in ILC2s whereby genes encoding the key enzymes in glycolysis ( Figure 5E ) and the TCA cycle ( Figure 5F ) were expressed at demonstrably lower levels compared to controls
ROS are formed as a result of incomplete reduction of oxygen and can be produced by mitochondrial electron transport chains (ETC) and enzymatic reactions such as NADPH oxidases (NOXs) [31]
Additionally, we found that weight loss was greater for patients without type 2 diabetes than for those with evidence of type 2 diabetes, though differences in effectiveness between tirzepatide and semaglutide were similar
Regarding chronic inflammation regulation, M2 macrophage exosomes encapsulated in degradable PEG hydrogels (Exogels) enable sustained release, promoting local macrophage transition from M1 to M2 phenotype and improving tissue repair (307)
