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While ROS can function as second messengers regulating cellular reproduction, growth, differentiation, and signaling when maintained at optimal concentrations and dynamic equilibrium, exceeding critical ROS thresholds induces oxidative stress, leading to DNA damage, protein denaturation, and lipid peroxidationkey factors in CHD development

Besides passive diffusion across bilayer membranes, uptake or efflux via membrane transporter molecules is of high significance for compound absorption, distribution and elimination (1416)

Am J Physiol Heart Circ Physiol 307:H1120H1133

Introduction The human body is a complex system, constantly working to maintain balance and health