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There was a clear need for a method to synthesize glucagon by less-herculean means that could be scaled enough for clinical investigation
Lipid and electroosmosis enhanced transdermal delivery of insulin by electroporation
More concerning, though rare, is the risk of acute pancreatitis, which has been reported with GLP-1 receptor agonists and is noted in the Warnings and Precautions sections of the prescribing information
Dong, S., Rodger, J., Mulders, W
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