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GI side effects improve

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[Accessed 24 May 2026] Lilly's SURMOUNT-1 results published in the New England Journal of Medicine show tirzepatide achieved between 16.0% and 22.5% weight loss in adults with obesity or overweight

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Combined with resistance training, the effect is even more pronounced, with creatine users maintaining 95% of their muscle mass compared to 85% in control groups

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[3] At the 12 mg dose, the mean weight reduction was about 17.5% at 24 weeks (the primary endpoint) rising to roughly 24.2% at 48 weeks , compared with about 2.1% for placebo

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