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NHS England (2021) National diabetes audit, 2020-21 type 1 diabetes
It separately flags hypoglycemia risk if both agents lower blood glucose meaningfully, and says that risk is higher in people already taking insulin or other glucose-lowering medications
The PIONEER series of clinical trials, called Peptide Innovation for Early Diabetes Treatment, aimed to establish the clinical role of oral semaglutide
Summary While GLP-1 receptor agonists offer some benefits in managing Type 2 diabetes and obesity, they come with notable drawbacks, including dependency on medication and a range of side effects, from gastrointestinal discomfort to severe adverse events like thyroid tumors and pancreatitis
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