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And thats why it seems to provide significant weight loss," the GoodRx website states
Metformin, an antidiabetic drug, inhibits the cAMP/CREB/MITF axis leading to the downregulation of the expression of tyrosinase, Tyrp1 and Tyrp2, and ultimately to the decrease of melanin production [99]
Phase 2 data showing 24% body weight loss is in humans, not mice but Phase 3 scale and long-term safety data are still pending
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