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The magnitude of weight change observed in some DIO studies appeared to exceed that reported for GLP-1R single agonists under comparable conditions in the same model systems [VERIFY]

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injections (between 15:00 and 17:00) of 100 nmol kg 1 MK-801, 10 nmol kg 1 semaglutide, 100 nmol kg 1 GLP-1MK-801 or vehicle, with concomitant measurements of body weight and food intake