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A limitation of our study is that we identified only FGF21 as an important cytokine involved in GCGR mAb-induced beta cell regeneration but there might be other cytokines and metabolites that contribute to beta cell regeneration under this condition
Obesity is one of the biggest health concerns, killing more than 2.8 million people every single year [1]
At 48 weeks, mean percentage changes in body weight from baseline were approximately: In the 12 mg arm, roughly 100% of participants achieved at least 5% body-weight loss, about 83% reached 15% loss, around 63% achieved 20% loss, and approximately 26% crossed the 25% threshold
These genetic factors deserve weight in any risk assessment
