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Best Practices: Adhere to researched doses and routes, and monitor closelyhuman synergy data remain limited
More common side effects of Zepbound and Wegovy are similar as both commonly cause digestive side effects, including nausea or vomiting
In a meta-analysis 6 of eight trials with 60080 patients (ELIXA, LEADER, SUSTAIN-6, EXSCEL, Harmony Outcomes, REWIND, PIONEER 6, and AMPLITUDE-O) , treatment with a GLP-1 receptor agonist led to a 14% relative risk reduction in three-point MACE (HR 086 [95% CI 080093]
It pairs with a baseline health assessment covering fasting glucose, lipids, kidney function, cardiovascular history, and family history of medullary thyroid cancer, which is flagged as an important safety contraindication
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