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Rat studies have noted embryofetal mortality, structural abnormalities, and alterations to growth at maternal exposures below the maximum recommended human dose (MRHD) based on exposure AUC
42 Metformin interferes with oxidative phosphorylation in mitochondria and stimulates osteogenic differentiation via AMPK, which is known to promote osteogenic and suppress adipogenic differentiation, although the exact mechanism of this action is unknown
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