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In our study, FOXO4-DRI selectively induced apoptosis in senescent keloid fibroblasts by promoting the relocation of p53-pS15 from the nucleus to the cytoplasm, exhibiting similar clearance efficiency to that in normal skin fibroblasts

26,27 Weight gain is likely to have implications for patients physical and mental well-being, and the combination of T2D and obesity has been shown to negatively impact QOL

however, it can also raise hepatic glucose output and heart rate, and the net clinical effects of this component in humans are still being characterised in ongoing trials

It can not only indicate the occurrence and progression of diseases but also mediate interorgan crosstalk