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GLP-1RAs and cardiovascular-renal outcomes in type 2 diabetes systematic review (2021) highlights significant reductions in cardiovascular events, kidney disease progression, and mortality among GLP-1 users
Separate high-dose oral b12 (1000 to 2000 mcg daily) or regular b12 injections (1000 mcg weekly or monthly) offer more reliable repletion
Manufacturers recommend refrigeration immediately after first puncture
Once the bodys receptors are saturated, any additional B12 is simply filtered out by the kidneys
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