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SURMOUNT-1 Tirzepatide in Participants With Obesity or Overweight
While cagrilintide activates amylin receptors to reduce appetite and slow gastric emptying, semaglutide stimulates GLP-1 receptors to enhance insulin secretion, suppress glucagon, and promote satiety through distinct neural pathways
This leads to the release and cytoplasmic translocation of p53, which can subsequently activate transcription-independent pro-apoptotic signaling (Clara et al., 2024
Cognitive clarity and brain protection occur because glutathione crosses the blood-brain barrier
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