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doi:10.1089/jmf.2022.0042

The study protocol received approval from Chi Mei Hospitals institutional review board in Tainan, Taiwan

Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W (1993) Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus

Mechanistically, ALC exerts its antidepressant effects via multiple pathways, including enhancement of mitochondrial function, upregulation of brain-derived neurotrophic factor (BDNF), modulation of glutamatergic neurotransmission, and epigenetic regulation of gene expression involved in mood regulation