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Evidence Snapshot (preclinical context) Important: The studies below are primarily animal or in vitro
But long-term GH replacement therapy (which produces similar GH/IGF-1 levels) has been studied for decades and is considered safe when properly monitored
Renal Impairment Safety, efficacy, and pharmacokinetics of tesamorelin in patients with renal impairment have not been established
However, with the maturation of neurons, mitochondrial trafficking significantly declines [42, 43]
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