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While some individual patients have reported experiencing leg pain while taking Zepbound, it is important to distinguish between a documented causal relationship and temporal associationjust because leg pain occurs during Zepbound treatment does not necessarily mean the medication directly causes it

It is crucial to understand that semaglutide's effects on insulin resistance are largely mediated through weight reduction and improved glycemic control rather than direct insulin-sensitizing action like metformin or thiazolidinediones

Tablets are generally more stable than liquid formulations and may not require refrigeration

Savino W, Dardenne M