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Author contributions Formulation or evolution of overarching research goals and aims: DAG, ASK, DJE, JBK, PML, VMJ, JPF Data curation: JBK, DRD, PML, JPF Application of statistical and/or mathematical analyses: ARS, JBK, DRD, CB, JPF Acquisition of funding: VMJ Conducting the research and/or collecting data: DAG, ASK, AMM, CL, SWB, ARS, SH, DJE, MCG, JBK, DRD, JMD, VMJ, JMC, CB, RBR, DJL, JPF, YL, DAT, MSL Project administration: MSL, DAP Provision of study resources including animals and patients: VMJ, MSL Implementation of the relevant software or computer programs: CB Oversight and leadership of the study planning and execution: DAG, ARS, SH, DJE, JBK, PML, JMD, VMJ, CB, DJL, JPF, MSL Data verification and validation: ASK, SWB, ARS, DWP, MCG, JBK, DRD, PML, CB, JPF, DAT, MSL Preparation of the data and graphical elements of the paper: DAG, ASK, CL, DWP, DJE, JBK, DRD, PML, JMD, CB, JPF, YL, DAT Preparation of the written elements of the paper: DAG, ASK, CL, ARS, DWP, DJE, JBK, DRD, PML, JMD, JPF, YL Editing and reviewing of the paper: DAG, ASK, AMM, CL, SWB, ARS, DWP, SH, DJE, MCG, JBK, DRD

The experiments involved 6- to 12-week-old male mice with a C57BL/6J genetic background