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The GI burden is real and additive
They work through different receptor pathways (amylin and GLP-1 respectively) and are injected separately at different sites on the same day
2.4% with placebo Responder rate (5% weight loss): 86.4% of semaglutide patients Responder rate (10% weight loss): 69.1% of semaglutide patients Responder rate (15% weight loss): 50.5% half of all patients lost at least 15% Common side effects: Nausea (44.2%), diarrhea (31.5%), vomiting (24.8%), constipation (24.2%) The magnitude of difference is striking: semaglutide produced nearly double the weight loss of liraglutide (14.9% vs
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