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Anxiety-like behavior In male rats, supplementation with leucine (P20-60), did not reduce POS-induced anxiety-like behavior in the OFT at P60 [105]
These drugs were promising early on, but many were abandoned for either failing to show clear benefits or for allegedly causing severe side effects
For example, in the ADJUNCT ONE trial, the rate of nausea with the highest dose of liraglutide (1.8mg) was 49.6% compared to 12.1% in the placebo
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