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For all in vitro studies, PNP hydrogel formulations comprising semaglutide were denoted with an S followed by their corresponding drug loading (e.g., S-1.8 mg/mL), while liraglutide formulations were denoted with an L followed by their corresponding drug loading (e.g., L-1.8 mg/mL)

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However, the researchers found a link between a reduction in waist circumference and heart benefits, which accounts for one-third of the drugs protective effect on the heart after two years