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[19] [21] Dosage adjustments may be necessary in patients with renal impairment, G6PD deficiency, or other comorbidities

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1 H NMR (500 MHz, DMSO) 7.95 (t, J = 38.4 Hz, 5H), 7.41 (p, J = 5.1, 3.9 Hz, 18H), 7.23 (d, J = 7.4 Hz, 2H), 7.09 (d, J = 7.4 Hz, 12H), 6.96 (d, J = 19.0 Hz, 2H), 6.70 (q, J = 9.2, 8.1 Hz, 4H), 4.56 (d, J = 54.2 Hz, 2H), 4.18 (d, J = 69.9 Hz, 3H), 3.56 (tt, J = 18.3, 9.3 Hz, 7H), 3.03 2.77 (m, 10H), 1.66 1.20 (m, 54H)

FIGURE 4 Immunohistochemical expression of SIRT-1 in the hepatic tissue among different experimental groups Both the control and PA groups showed positive SIRT-1 expression, but the APAP group showed weak positive SIRT-1 expression