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Additionally, Fer-1 has been shown to mitigate the decline in cellular function resulting from prominin2 depletion (Yan et al., 2022 discovered that the small molecule protein-protein interaction (PPI) inhibitor K-181 could suppress p53 transcription and ameliorate neurological impairments post-ischemic stroke (IS) by increasing the expression of the p53 repressor Mdmx, consequently inhibiting p53 transcription in the brains of mice following IS

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