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A glutathione reductase mutant of yeast accumulates high levels of oxidized glutathione and requires thioredoxin for growth

In SUSTAIN-6, use of once-weekly semaglutide led to an increased risk of diabetic retinopathy worsening (HR 176, 95% CI 111 276) [1], and it has been speculated that this can likely be attributed to early worsening given the rapid improvement in glycemic control in the semaglutide arm [21]

The FDA has also indicated that gene therapies may qualify for orphan drug designation in most of the genetic conditions currently being targeted, adding seven years of ODE on top of biologic exclusivity

For example, if a battery is labeled 3000mAh at the one-hour rate, its 1C rating is 3000mAh