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Across these systems, early clinical or translational setbacks were frequently interpreted as evidence of flawed biology rather than limitations in pharmacologic engineering, dosing paradigms, or endpoint selection
2 : GLP-1 2
The Diabetes Control and Complications Trial research group previously observed that early worsening of diabetic retinopathy can occur with intensive glycemic control, though effective glycemic control ultimately lowers retinopathy risk over the long-term
Nevus of Ito is common in Asian and black skin types, and more common in females than males [72]
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