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18 patient's genes localized their harmful mutations or deletion on both the alleles, while 4 of them found their causative mutations on one of the two alleles, and 1 failed to find any responsible mutation

doi:10.1155/2021/6564585 [Made by author on BioRender] The interactions of these different cell types together with efficient junctions and the multilayer structure ensure protection of the brain from harmful substances

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This approach may overestimate frailty and does not incorporate important physical domains of frailty such as strength, exhaustion, slowness, and weakness