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The advantage of SGLT-2 inhibitors is that they are glycemic dependent that means they cause the user to urinate excess glucose when blood sugars are high, but they stop working when blood sugars are low
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Exendin-4, isolated from Heloderma suspectum venom, showed that a naturally protease-resistant GLP-1 receptor agonist was possible, but it is a different molecule from human GLP-1 and carries different immunogenicity considerations
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