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Reduction of other inflammatory biomarkers has also been reported following GLP-1RA treatment in rodent models of cerebral ischemia, namely myeloperoxidase, IL-1, IL-6, IL-18, and cyclooxygenase-2 (COX-2), the latter through increasing expression of islet-brain-1 (IB1) [72,73,74]

It mimics growth-hormone-releasing hormone at the pituitary for a brief window (~30 minutes), nudging out a pulse of GH without driving a sustained, tonic rise in IGF-1

Side effects The most common side effects include nausea, vomiting, and diarrhea, necessitating a slow titration of the dose to ensure tolerance