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Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

As people eat less junk food, major packaged-food companies are seeing the impact on sales and pivoting in an attempt to maintain consumer appetites.[1,2] Glucagon-like peptide-1 (GLP-1) receptor agonists were first approved in the United States in 2005 for the treatment of diabetes and in 2014 for weight loss.[3] Their cultural footprint expanded dramatically after semaglutide received approval for weight management in 2021.[3,4] Today, whether scrolling social media or chatting with friends, patients, or colleagues, its impossible not to notice the sweeping influence of Wegovy, Ozempic, and similar medications

11 Packer MZile MRKramer CM Tirzepatide 2025;392:427-37

Reversible protein phosphorylation is governed by protein kinases and phosphatases