The main trade-off is cosmetic
GAD patients demonstrated broader SCFA depletion, with decreased levels of Faecalibacterium, Eubacterium rectale, Butyricicoccus , and Lachnospira , bacteria integral to maintaining mucosal homeostasis and modulating host-microbiota immune interactions
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Intracellular metabolite concentrations have to fine-tune the signaling networks governing metabolic pathways independently of the environment to ensure a balance between the availability of nutrients and the cellular capacity to use them effectively