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Interestingly, the mutation of ATP4Ap.R703C leads to gastric acid deficiency, and the disturbance of pH balance can directly affect the physiological function of the mitochondrial respiratory chain, causing ROS signaling to be activated and triggering caspase-3-mediated apoptosis in the host cells (Bentez et al., 2020)
Statins remain the cornerstone of cholesterol management according to NICE guidance, whilst GLP-1 agents provide complementary lipid benefits when prescribed for their licensed indications of type 2 diabetes or obesity
Extending our understanding of exenatide: a rare case of angio-oedema
Semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an East Asian population (STEP 6): a randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial
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