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66 In contrast, preserving GSH by supplementing cysteine or GSH precursors helps bacteria survive oxidative challenge
IF can also modulate glucose metabolism, reduce systemic inflammation, and enhance critical indicators of cardiovascular health, underscoring its potential as a non-pharmacological strategy for long-term disease prevention and overall health enhancement [2, 64]
Mechanistic studies using CRISPR/Cas9-engineered cell lines bearing the C65G mutation revealed a multilayered disruption of tRNA [Ser]Sec function: reduced tRNA expression, severe impairment of selenoprotein synthesis, and most strikingly a loss of selenium responsiveness not observed with other tRNA [Ser]Sec mutants [111]
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